SB 239063 | p38 MAPK 抑制剂 | MCE

来自 : www.medchemexpress.cn/SB-2390. 发布时间：2021-03-24

The protective role of p38 MAPK inhibition in II/R-induced ALI and regulation of AQP4 in rats. HE staining and Lung wet/dry weight ratio show obvious evidences of ALI and lung edema. Western blot and immunofluorescent staining confirm the increased expression levels of AQP4 and P-p38 MAPK protein in the lung tissues. Then, the p38 MAPK inhibitor is administrated intraperitoneally. Results show that p38 MAPK inhibition downregulates AQP4 expression in the lungs and protected lung from acute injur
SB 239063 Chemical Structure CAS No. : 193551-21-2 SizePriceStockQuantity 10 mM * 1 mL in DMSO ￥892 In-stock 1 mg ￥500 In-stock 5 mg ￥...SB 239063 | SB239063 | SB-239063 | p38 MAPK | Autophagy | Inhibitor | inhibitor | inhibitSB 239063 是一种有效、选择性、可口服的 p38 MAPK 抑制剂，对重组纯化的人 p38α 的 IC50 值为 44 nM，对 p38α 和 p38β 的活性等效，但对 p38γ 或 p38δ 无所用。具有抗哮喘作用，还被用于增强因衰老或疾病受损的记忆，如阿尔茨海默病。- 高纯度，全球文献引用。SB 239063