美国APExBIO中文官网 - SB 204990

来自 : www.apexbio.cn/sb-2049...html 发布时间：2021-03-24

BackgroundChemical Properties质量控制Background

SB 204990 is a specific inhibitor of ATP citrate lyase (ACLY) enzyme.

In HepG2 cells, SB 204990 inhibits fatty acid and cholesterol synthesis in a concentration-dependent manner. Oral administration of SB 204990 (25 mg/kg) reduces plasma levels of the lipoproteins VLDL, LDL, and HDL by 21, 40, and 22%, respectively, in dogs. It also reduces VLDL synthesis and plasma cholesterol and triglyceride levels in rats in a dose-dependent manner.

Reference:

[1]. Pearce N J, Yates J W, Berkhout T A, et al. The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076. Biochem J, 1998,  334(1): 113-119.

Chemical PropertiesPhysical AppearanceWhite solidStorageStore at -20°CM.Wt389.27Cas No.154566-12-8FormulaC18H22Cl2O5SolubilitySoluble in DMSOChemical Name2-((3S,5R)-5-(6-(2,4-dichlorophenyl)hexyl)-3-hydroxy-2-oxotetrahydrofuran-3-yl)acetic acidSDFDownload SDFCanonical SMILESClC1=CC(Cl)=C(C=C1)CCCCCC[C@](O2)([H])C[C@](C2=O)(O)CC(O)=O运输条件试用装：蓝冰运输。 其他可选规格：常温运输或根据您的要求用蓝冰运输。一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。质量控制 质量控制和MSDS
Background Chemical Properties 质量控制 Background SB 204990 is a specific inhibitor of ATP citrate lyase (ACLY) enzyme. In HepG2 cells, SB 204990 ...抑制剂，小分子，激动剂，拮抗剂，分子库，化合物库，蛋白酶，磷酸酶，聚合酶，试剂盒，核苷酸，mRNA，DNASB 204990 is a specific inhibitor of ATP citrate lyase (ACLY) enzyme. In HepG2 cells, SB 204990 inhibits fatty acid and cholesterol synthesis in a concentration-dependent manner. Oral administration of SB 204990 (25 mg/kg) reduces plasma levels of the li美国APExBIO中文官网